logo
▶ About us
▶ News & Events
▶ For Physicians
▶ How you can help
▶ Site Map
Sign up for our mailing list!
 
Visit our Facebook page
 
Exercise and Thalassemia
 
New Fetal Transplant Study
 
Thalassemia Adoption Clinic
 
 
 
 
 
Sign up for our newsletter
 
Story of an Alpha Thalassemia Baby


Treating Thalassemia

Treating Thalassemia
▶ DNA Testing
▶ Transfusion
▶ Chelation
    » Introduction
    » Desferal
        --Desferal guide
    » Exjade
    » L1
    » Combination
▶ Splenectomy
▶ Thromboembolic disease
▶ Hemoglobin H disease:
    » Overview
    » Guidelines
▶ Iron Measurement
▶ SQUIDS Across the Globe
▶ Bone Health
▶ Thalassemia Checklist
▶ Bone marrow transplant
    » HLA genetics
    » BMT factsheet
▶ Hydroxyurea
▶ Standard of Care Guidelines
▶ Non-transfusion-dependent thalassemia: TIF guidelines
▶ Non-transfusion-dependent thalassemia: Review
▶ Intrauterine Therapy for Alpha Thal Major
▶ Fetal Transplant Study
 
Thalassemia Standard-of-Care Guidelines (mobile optimized)
SOC QR
 

THROMBOEMBOLIC DISEASE

People with thalassemia are at increased risk of thrombosis.

Thrombotic events include pulmonary embolism, arterial occlusion, portal thrombosis, and deep vein thrombosis. Approximately 1 to 2 percent of thalassemia major patients and 5 percent of thalassemia intermedia patients experience a serious thrombosis.

One of the most common and serious complications is stroke. Recent brain MRI studies suggest that thalassemia patients (particularly those with thalassemia intermedia) are at high risk for subclinical infarction or silent stroke. Splenectomy significantly increases the prevalence of thrombotic events. Inadequate transfusion may increase the risk of thrombosis secondary to increased release of procoagulant red cell particles. Many people recommend that all post-splenectomy patients should receive anti-platelet or anti-thrombosis therapy with aspirin or low dose warfarin.

Post-splenectomy thrombocytosis is common, and low-dose aspirin should be given during this time. Another complication following splenectomy is the development of a thrombophilic state. Venous thromboembolism, more common in thalassemia intermedia and hemoglobin H–Constant Spring, can develop following splenectomy.


Northern California Comprehensive Thalassemia Center
UCSF Benioff Children's Hospital Oakland
747 52nd Street, Oakland CA 94609   •   Phone: (510) 428-3651   •   Fax: (510) 450-5647
© 2003-2012 Children's Hospital & Research Center Oakland
Facebook logo Twitter logo Youtube logo Blogger logo
| Home | Our Program | Contact Us | For physicians | What is thalassemia? | Genetics | Treatment | Research | Living with thalassemia | Site Map |